Publications

Research papers

  1. Hiragi K, Nishide A, Takagi K, Iwai K, Kim M*, Mizushima T*; Structural insight into the recognition of the linear ubiquitin assembly complex by Shigella E3 ligase IpaH1.4/2.5. J Biochem. 2023 Jan 4; https://doi.org/10.1093/jb/mvac109 KURENAI:http://hdl.handle.net/2433/281537
  2. Akira N, Takagi K, Minsoo K, Tsunehiro M; Active site structure of the Shigella flexneri　effector OspI. bioRxiv, 2022. doi: https://doi.org/10.1101/2022.02.15.480433
  3. Fuseya Y, FujitaH, Kim M, Ohtake F, NishideA, Sasaki K, SaekiY, TanakaK, TakahashiR, Iwai K; The HOIL-1L ligase modulates immune signaling and cell death by mono-ubiquitination of LUBAC. Nat Cell Biol, 2020 June; 22,663-673
  4. Takeda M, Tezuka T, Kim M, Choi J, Oichi Y, Kobayashi H, Harada K, Mizushima T, Taketani S, Koizumi A, Youssefian S; Moyamoya disease patient mutations in the RING domain of RNF213 reduce its ubiquitin ligase activity and enhance NF-kB activation and apoptosis in an AAA+domain-dependent manner. Biochem Biophys Res Commun, 2020 May; 525(3):668-674
  5. Yamamoto M§, Kim M§, Imai H§, Itakura Y, Ohtsuki G; Microglia-triggered plasticity of intrinsic excitability modulates psychomotor behaviors in acute cerebellar inflammation. Cell Rep. 2019 Sep; 28 (11):2923-2938   
  6. Otsubo R, Kim M*, Lee J, Sasakawa C*; Midori-ishi Cyan/monomeric Kusabira-Orange-based fluorescence resonance energy transfer assay for characterization of various E3 ligases.Genes Cells. 2016 Jun; 21(6):608-623.
  7. Takagi K, Kim M, Sasakawa C, Mizushima T; Crystal structure of the substrate-recognition domain of the Shigella E3 ligase IpaH9.8. Acta Crystallogr F Struct Biol Commun. 2016 Apr; F72(Pt 4):269-275.
  8. Suzuki S, Mimuro H, Kim M, Ogawa M, Ashida H, Toyotome T, Franchi L, Suzuki M, Sanada T, Suzuki T, Tsutsui H, Nunez G, Sasakawa C; Shigella IpaH7.8 E3 ligase targets glomulin and activates inflammasomes to demolish macrophages. Proc Natl Acad Sci USA. 2014 Oct; 111(40): E4254-63.
  9. Kiga K, Mimuro H, Suzuki M, Shinozaki-Ushiku A, Kobayashi T, Sanada T, Kim M, Ogawa M, Iwasaki Y, Kayo H, Fukuda-Yuzawa Y, Yashiro M, Fukayama M, Fukao T, Sasakawa C; Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection. Nat Commun. 2014 Sep; 5:4497.
  10. Nishide A, Kim M*, Takagi K, Himeno A, Sanada T, Sasakawa C, Mizushima T*; Structural basis for the recognition of Ubc13 by the Shigella flexneri effector OspI. J Mol Biol. 2013 Aug; 425(15):2623-2631.
  11. Kobayashi T, Ogawa M, Sanada T, Mimuro H, Kim M, Ashida H, Akakura R, Yoshida M, Kawalec M, Reichhart J, Mizushima T, Sasakawa C; The Shigella OspC3 Effector Inhibits Caspase-4, Antagonizes Inflammatory Cell Death, and Promotes Epithelial Infection. Cell Host Microbe. 2013 May; 13(5):570-583.
  12. Takeshita K, Tezuka T, Isozaki Y, Yamashita E, Suzuki M, Kim M, Yamanashi Y, Yamamoto T, Nakagawa A; Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c. J Biochem. 2012 Nov;152(5):487-495.
  13. Fukumatsu M, Ogawa M, Kim M, Mimuro H, Sasakawa C; Uptake of Shigella-containing pseudopodia by neighboring epithelial cells at tricellular junctions via non-canonical clathrin-dependent trafficking pathway. Virulence, 2012 Oct; 3(6): 515-517.
  14. Sanada T, Kim M, Mimuro H, Ashida H, Ogawa M, Mizushima T, Sasakawa C; A bacterial effector targets the TRAF6-NFkB pathway to modulate the acute inflammatory response to bacterial invasion of epithelial cells. Virulence, 2012 Oct;3(6): 518-520.
  15. Sanada T, Kim M, Mimuro H, Suzuki M, Ogawa M, Oyama A, Ashida H, Kobayashi T, Koyama T, Nagai S, Shibata Y, Ghoda J, Inoue J, Mizushima T, Sasakawa C; The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. Nature. 2012 Mar; 483(7391):623-626.
  16. Kawauchi K, Tan WW, Araki K, Abu Bakar FB, Kim M, Fujita H, Hirata H, Sawada Y; p130Cas-dependent actin remodeling regulates myogenic differentiation. Biochemical J.2012 Aug; 445(3):323-332.
  17. Fukumatsu M, Ogawa M, Arakawa S, Suzuki M, Nakayama K, Shimizu S, Kim M, Mimuro H, Sasakawa C; Shigella targets epithelial tricellular junctions and uses a noncanonical Clathrin-dependent endocytic pathway to spread between cells. Cell Host Microbe. 2012 Apr; 11(4):325-336.
  18. Suzuki T, Kim M, Kozuka-Hata H, Watanabe M, Oyama M, Tsumoto K, Yamamoto T; Monoubiquitination of Tob/BTG family proteins competes with degradation-targeting polyubiquitination. Biochem Biophys Res Commun, 2011 May; 409 (1):70-74.
  19. Watanabe M, Suzuki T, Kim M, Abe Y, Yoshida Y, Sugano S, Yamamoto T; Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. FEBS Lett. 2011 Jan 3; 585 (1):65-70.
  20. Morikawa H, Kim M*, Mimuro H, Punginelli C, Koyama T, Nagai S, Miyawaki A, Iwai K, Sasakawa C; The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1. Biochem Biophys Res Commun. 2010 Oct;401 (2):268-274.
  21. Ashida H, Kim M, Schmidt-Supprian M, Ma A, Ogawa M, Sasakawa C; A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKg to dampen the host NF-kB-mediated inflammatory response. Nat Cell Biol. 2010 Jan; 12 (1):66-73.
  22. Kim M, Ogawa M, Mimuro H, Sasakawa C; Reinforcement of epithelial cell adhesion to basement membrane by a bacterial pathogen as a new infectious stratagem. Virulence. 2010 Jan-Feb; 1 (1): 52-55.
  23. Yoshikawa Y, Ogawa M, Hain T, Yoshida M, Fukumatsu M, Kim M, Mimuro H, Nakagawa I, Yanagawa T, Ishii T, Kakizuka A, Sztul E, Chakraborty T, Sasakawa C; Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nat Cell Biol. 2009 Oct;11 (10):1233-1240.
  24. Kim M, Ogawa M, Fujita Y, Yoshikawa Y, Nagai T, Koyama T, Nagai S, Lange A, Fassler R, Sasakawa C; Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. Nature. 2009 May; 459 (7246):578-582.
  25. Kim M, Nakamoto T, Nishimori S, Tanaka K, Chiba T; A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation. EMBO reports. 2008 Sep; 9 (9):878-884.
  26. Iwai H§, Kim M§, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson K. P, Kotani S, Sasakawa C; A Bacterial Effector Targets Mad2L2, an APC Inhibitor, to Modulate Host Cell Cycling. Cell. 2007 Aug; 130 (4):611-623.
  27. Kim M, Tezuka T, Tanaka K, Yamamoto T; Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. Oncogene. 2004 Mar; 23 (9):1645-1655.
  28. Kim M, Tezuka T, Suzuki Y, Sugano S, Hirai M, Yamamoto T; Molecular cloning and characterization of a novel cbl-family gene, cbl-c. Gene. 1999 Oct; 239 (1):145-154.

*Corresponding author, §equal contribution

Reviews

  1. Kim M*, Otsubo R, Morikawa H, Nishide A, Takagi K, Sasakawa C, Mizushima T; Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition. Cells. 2014 Aug; 3(3), 848-864.
  2. Ashida H, Kim M, Sasakawa C; Manipulation of the host cell death pathway by Shigella. Cell Microbiol. 2014 Dec; 16(12):1757-1766.
  3. Ashida H, Kim M, Sasakawa C; Exploitation of the host ubiquitin system by human bacterial pathogens. Nat Rev Microbiol. 2014 Jun; 12(6): 399-413.
  4. Ashida H, Ogawa M, Kim M, Mimuro H, Sasakawa C; Bacteria and host interactions in the gut epithelial barrier. Nat Chem Biol. 2011 Dec; 8(1): 36-45.
  5. Ashida H, Mimuro H, Ogawa M, Kobayashi T, Sanada T, Kim M, Sasakawa C; Cell death and infection: A double-edged sword for host and pathogen survival. J Cell Biol. 2011 Dec; 195(6): 931-42.
  6. Kim M, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Sasakawa C; Bacterial interactions with the host epithelium. Cell Host Microbe. 2010 Jul; 8(1): 20-35.
  7. Ashida H, Ogawa M, Kim M, Suzuki S, Sanada T, Punginelli C, Mimuro H, Sasakawa C; Shigella deploy multiple countermeasures against host immune response. Curr Opin Microbiol. 2010 Feb; 14(1):16-23.

Japanese Reviews

  1. 西出旭、金玟秀; 「病原細菌によるユビキチン修飾系撹乱の分子機構」 生化学、92(1)，1-9 (2020)
  2. 金玟秀；「病原細菌による宿主粘膜感染の分子機構の解明」、Journal of the society of Japanese women scientists, 17, 8-18 (2017)
  3. 金玟秀；「バクテリアの病原性とユビキチン関連修飾システム」、医学のあゆみ、256 (8),880-884 (2016)
  4. 金玟秀；「病原性バクテリアによるユビキチン修飾系の制御」、医学のあゆみ、243 (6), 535-540 (2012)